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Calmidazolium chloride
CAS No. 57265-65-3
Calmidazolium chloride ( R 24571 )
产品货号. M26084 CAS No. 57265-65-3
Calmidazolium氯化物是一种钙调蛋白 (CaMK) 拮抗剂 (Kd = 3 nM)，拮抗 CaM 依赖性磷酸二酯酶 (IC50 = 0.15 μM) 和钙调蛋白诱导的红细胞 Ca2+ 转运 ATP 酶激活 (IC50 = 0.35 μM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥462 | 有现货 |
|
| 10MG | ￥721 | 有现货 |
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| 25MG | ￥1199 | 有现货 |
|
| 50MG | ￥1831 | 有现货 |
|
| 100MG | ￥2730 | 有现货 |
|
| 200MG | ￥3977 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Calmidazolium chloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Calmidazolium氯化物是一种钙调蛋白 (CaMK) 拮抗剂 (Kd = 3 nM)，拮抗 CaM 依赖性磷酸二酯酶 (IC50 = 0.15 μM) 和钙调蛋白诱导的红细胞 Ca2+ 转运 ATP 酶激活 (IC50 = 0.35 μM)。
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产品描述Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.(In Vitro):Calmidazolium chloride inhibits growth of mouse F9 ECCs (IC50 = 8.18 μM) and E14 ESCs (IC50 = 12.69 μM).
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体外实验Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs. Cell Viability Assay Cell Line:Mouse F9 ECCs Concentration:3, 5, 7, 10 μM Incubation Time:30 minutes-24 hours Result:The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM.
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体内实验——
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同义词R 24571
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通路Endocrinology/Hormones
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靶点CaMK
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受体Autophagy| NF-κB| Reactive Oxygen Species
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研究领域——
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适应症——
化学信息
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CAS Number57265-65-3
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分子量687.69
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分子式C31H23Cl7N2O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (145.41 mM)
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SMILES[Cl-].Clc1ccc(cc1)C(c1ccc(Cl)cc1)[n+]1ccn(CC(OCc2ccc(Cl)cc2Cl)c2ccc(Cl)cc2Cl)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells.Chin Med. 2014 Apr 17;9:14.
产品手册
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